3821 results found for "stem cell"
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technical note
Automated Staining of Pluripotent Cells with Tra-1-60 and CellTracker Orange
An automated cell staining solution to assess single-cell heterogeneity and viability with two stains on the C1 System.
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event
ISSCR 2015
Discover what makes every stem cell unique from the inside out …
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event
ISSCR 2016
Single-cell resolution. Real insight. …
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article
Exploring Diversity with Single-Cell Clarity
Confidently scale your cell atlas or lineage study with the new C1 medium-cell HT IFC …
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Publications
Dok1 and Dok2 Proteins Regulate Cell Cycle in Hematopoietic Stem and Progenitor Cells
Dok1 and Dok2 proteins play a crucial role in myeloid cell proliferation as demonstrated by Dok1 and Dok2 gene inactivation, which induces a myeloproliferative disease in aging mice. In this study, we show that Dok1/Dok2 deficiency affects myeloproliferation even at a young age. …
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Publications
Effects of cellular origin on differentiation of human induced pluripotent stem cell–derived endothelial cells
Human induced pluripotent stem cells (iPSCs) can be derived from various types of somatic cells by transient overexpression of 4 Yamanaka factors (OCT4, SOX2, C-MYC, and KLF4). …
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Publications
CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells
The regulation of hematopoietic stem cell (HSC) survival and self-renewal within the bone marrow (BM) niche is not well understood. …
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Publications
Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy
The blood system is maintained by a small pool of haematopoietic stem cells (HSCs), which are required and sufficient for replenishing all human blood cell lineages at millions of cells per second throughout life. …
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Publications
Diabetes impairs the angiogenic potential of adipose-derived stem cells by selectively depleting cellular subpopulations
Pathophysiologic changes associated with diabetes impair new blood vessel formation and wound healing. …
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Publications
Patterning pluripotency in embryonic stem cells
Developmental gradients of morphogens and the formation of boundaries guide the choices between self-renewal and differentiation in stem cells. …
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article
The Haematopoietic Stem Cell Lab
Developing stem cell treatments at Cambridge Institute for Medical Research …
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Publications
Cell expansion during directed differentiation of stem cells toward the hepatic lineage
The differentiation of human pluripotent stem cells (hPSCs) towards the hepatocyte lineage can potentially provide an unlimited source of functional hepatocytes for transplantation and extracorporeal bioartificial liver applications. …
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Publications
Small SSEA-4-positive cells from human ovarian cell cultures: related to embryonic stem cells and germinal lineage?
It has already been found that very small embyronic-like stem cells (VSELs) are present in adult human tissues and organs. …
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Publications
Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells
The endosteal niche is critical for the maintenance of hematopoietic stem cells (HSCs). …
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Publications
Single-Cell Analysis of Proxy Reporter Allele-Marked Epithelial Cells Establishes Intestinal Stem Cell Hierarchy
The recent development of targeted murine reporter alleles as proxies for intestinal stem cell activity has led to significant advances in our understanding of somatic stem cell hierarchies and dynamics. …
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Publications
Expression of Genes Related to Germ Cell Lineage and Pluripotency in Single Cells and Colonies of Human Adult Germ Stem Cells
The aim of this study was to elucidate the molecular status of single human adult germ stem cells (haGSCs) and haGSC colonies, which spontaneously developed from the CD49f MACS and matrix- (collagen−/laminin+ binding-) selected fraction of enriched spermatogonia. …
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Publications
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
Melanoma patients treated with oncogenic BRAF inhibitors can develop cutaneous squamous cell carcinoma (cSCC) within weeks of treatment, driven by paradoxical RAS/RAF/MAPK pathway activation. …
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Publications
Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells
Hematopoietic stem cells (HSCs) are a rare cell type with the ability of long-term self-renewal and multipotency to reconstitute all blood lineages. …
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Publications
Derivation of Diverse Hormone-Releasing Pituitary Cells from Human Pluripotent Stem Cells
Human pluripotent stem cells (hPSCs) provide an unlimited cell source for regenerative medicine. …
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Publications
Eradication of CML stem cells
Bcr-Abl tyrosine kinase inhibitors (TKIs) have become the standard of care for patients with chronic myeloid leukemia (CML). …