409 results found for "checkpoint inhibitor"
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Publications
VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer
To date, anti-CTLA-4 (ipilimumab) or anti-PD-1 (nivolumab) monotherapy has not been demonstrated to be of substantial clinical benefit in patients with prostate cancer. …
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faq
Which IFC is used for the Advanta Immuno-Oncology Gene Expression Assay panel?
96.96 Dynamic Array™ IFC for Gene Expression …
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faq
What is the sample RNA input amount for the Advanta Immuno-Oncology Gene Expression Assay?
2–100 ng of total RNA …
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faq
What sample types are supported for the Advanta Immuno-Oncology Gene Expression Assay?
Purified RNA from FFPE, fresh or fresh frozen tissue …
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faq
Do I have to purchase both of the subpanels of the Advanta Immuno-Oncology Gene Expression Assay?
No, the panels are sold separately in 2-pack IFCs (integrated fluidic circuits) and 10-pack IFCs or together in 4-pack IFCs and 20-pack IFCs. …
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faq
What is the Advanta Immuno-Oncology Gene Expression Assay?
The Advanta™ Immunology-Oncology Gene Expression Assay qPCR assay panel enables profiling of tumor immunobiology and identification of new biomarkers. …
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Publications
Immunotherapy-induced sarcoidosis in patients with melanoma treated with PD-1 checkpoint inhibitors: Case series and immunophenotypic analysis
Sarcoidosis is a multisystem granulomatous disease. …
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faq
I already have IFCs. Can I just buy the assays for the Advanta Immuno-Oncology Gene Expression Assay?
No, the reagents included in the Advanta™ Immuno-Oncology Gene Expression Assay have been analytically validated together to ensure optimal performance across all genes. …
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faq
What reagents are required to run the Advanta Immuno-Oncology Gene Expression Assay panel?
The assay is available in several configurations. …
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faq
How many genes are in the panel of the Advanta Immuno-Oncology Gene Expression Assay?
170 genes are assigned to two sets, designated as Panel A and Panel B. …
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article
On Phenotype and Function
Deeply profile T cell checkpoint response with mass cytometry immuno-oncology panels …
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faq
What are the part numbers for ordering the Advanta Immuno-Oncology Gene Expression Assay?
Part numbers are listed here. …
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faq
What are the genes in the panel for the Advanta Immuno-Oncology Gene Expression Assay?
The complete panel set includes genes for identification and functional analysis of immune and cancer cells. …
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Publications
Comprehensive characterization of VISTA expression in patients with acute myeloid leukemia
Acute myeloid leukemia (AML) is a candidate for novel therapeutics, specifically immune checkpoint (IC) inhibitors. …
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Publications
PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression
To explore whether a crosstalk exists between PARP inhibition and PD-L1/ PD-1 immune checkpoint axis, and determine if blockade of PD-L1/ PD-1 potentiates PARP inhibitor (PARPi) in tumor suppression. …
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Publications
Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma
Anti-tumour immune activation by checkpoint inhibitors leads to durable responses in a variety of cancers, but combination approaches are required to extend this benefit beyond a subset of patients. …
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Publications
In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemia
Although progress in children, in adults, ALL still carries a dismal outcome. …
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Publications
Myelodysplastic Syndrome Revealed by Systems Immunology in a Melanoma Patient Undergoing Anti-PD-1 Therapy
Antibodies aimed at blocking the interaction between programmed cell death-1 (PD-1) and its ligands have shown impressive efficacy in a variety of malignancies and are generally well tolerated. …
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Publications
Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma
We generated a comprehensive atlas of the immunologic cellular networks within human malignant pleural mesothelioma (MPM) using mass cytometry. …
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article
Webinar | Towards an assay of global immune competence
Holden Maecker discusses the need to develop a global assay of immunocompetence …