77 results found for "HIV"

• Publications

  Immune-Related Functions of the Hivep Gene Family in East African Cichlid Fishes

  Immune-related genes are often characterized by adaptive protein evolution. …

• Publications

  Histone Deacetylase Inhibitor Romidepsin Inhibits De Novo HIV-1 Infections

  Adjunct therapy with the histone deacetylase inhibitor (HDACi) romidepsin increases plasma viremia in HIV patients on combination antiretroviral therapy (cART). …

• Publications

  Early Preservation of CXCR5+ PD-1+ Helper T Cells and B Cell Activation Predict the Breadth of Neutralizing Antibody Responses in Chronic HIV-1 Infection

  Much is known about the characteristics of broadly neutralizing antibodies (bNAbs) generated during HIV-1 infection, but little is known about immunological mechanisms responsible for their development in only a minority of those infected by HIV-1. …

• Publications

  NK Cells in HIV Disease

  Natural killer (NK) cells play a critical role in viral immunity. In the setting of HIV infection, epidemiologic and functional evidence support a role for NK cells in both protection from new infection and in viral control. …

• Publications

  BCG vaccination induces HIV target cell activation in HIV-exposed infants in a randomized trial

  Bacillus Calmette-Guérin (BCG) vaccine is administered at birth to protect infants against tuberculosis throughout Africa, where most perinatal HIV-1 transmission occurs. …

• Publications

  Longitudinal dynamics of the HIV-specific B cell response during intermittent treatment of primary HIV infection

  Neutralizing antibodies develop in natural HIV-1 infection. …

• article

  Cracking the Immunity Code

  Oxford scientists discern macrophage signaling roles in HIV latency using Polaris …

• Publications

  Microdevices for examining immunological responses of single cells to HIV

  More than 60 million people in the world have been diagnosed with HIV infections since the virus was recognized as the causative agent of AIDS in the 1980s. …

• Publications

  Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia

  CD4+ T cells play a pivotal role in the control of chronic viral infections. …

• media

  Webinar | Signatures of protective NK cell responses

  Catherine Blish describes her work to reveal the vast diversity of the NK repertoire …

• Publications

  A transcriptome-based model of central memory CD4 T cell death in HIV infection

  Human central memory CD4 T cells are characterized by their capacity of proliferation and differentiation into effector memory CD4 T cells. …

• Publications

  Impact of Chronic HIV/SIV Infection on T Follicular Helper Cell Subsets and Germinal Center Homeostasis

  The discovery of broad and potent HIV-1 neutralizing antibodies (bNAbs) has renewed optimism for developing an effective vaccine against HIV-1. …

• Publications

  Mass cytometric analysis of HIV entry, replication, and remodeling in tissue CD4+ T cells

  To characterize susceptibility to HIV infection, we phenotyped infected tonsillar T cells by single-cell mass cytometry and created comprehensive maps to identify which subsets of CD4+ T cells support HIV fusion and productive infection. …

• Publications

  HIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation

  Follicular helper T (Tfh) cells within secondary lymphoid organs control multiple steps of B cell maturation and antibody (Ab) production. …

• Publications

  The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes

  Follicular helper CD4+ T cells (TFH) play an integral role in promoting B cell differentiation and affinity maturation. …

• Publications

  T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response

  Humoral immunity is critical for viral control, but the identity and mechanisms regulating human antiviral B cells are unclear. …

• Publications

  Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells

  The highly polymorphic human leukocyte antigen (HLA) locus encodes cell surface proteins that are critical for immunity. …

• Publications

  New assays for monitoring residual HIV burden in effectively treated individuals

  Measurements of HIV burden have relied upon quantification of viral nucleic acids by real-time PCR (qPCR). To develop and test strategies for eradication, new methods are needed to better characterize residual cellular reservoirs in patients on suppressive antiretroviral therapy (ART). …

• Publications

  Novel HIV IL-4R antagonist vaccine strategy can induce both high avidity CD8 T and B cell immunity with greater protective efficacy

  We have established that the efficacy of a heterologous poxvirus vectored HIV vaccine, fowlpox virus (FPV)-HIV gag/pol prime followed by attenuated vaccinia virus (VV)-HIV gag/pol booster immunisation, is strongly influenced by the cytokine milieu at the priming vaccination site, with endogenous IL-13 detrimental to the quality of the HIV specific CD8+ T cell response induced. …

• Publications

  Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection

  Despite the overwhelming benefits of antiretroviral therapy (ART) in curtailing viral load in HIV-infected individuals, ART does not fully restore cellular and humoral immunity. …