304 results found in Single-Cell Genomics

• safety data sheet

  C1 Loading Reagent 

• technical note

  C1 System Site Requirements 

  C1 system Site Requirements v M1

• User Guide

  Genomics Instruments Safety Guide 

  Safety Information for Genomics Instruments

• system

  C1

  The first automated solution for single-cell genomics, now capable of even more …

• Publications

  Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA

  Plasma of cancer patients contains cell-free tumor DNA that carries information on tumor mutations and tumor burden. …

• media

  A Novel, Multifactorial Approach for hiPSC Differentiation and Reprogramming Using an Automated Cell Culture System 

  A major challenge in the stem cell field is to define the optimal condition for cell expansion, differentiation and reprogramming.

• Publications

  NGS-Logistics: federated analysis of NGS sequence variants across multiple locations

  As many personal genomes are being sequenced, collaborative analysis of those genomes has become essential. …

• Publications

  Single-cell genetic analysis using automated microfluidics to resolve somatic mosaicism

  Somatic mosaicism occurs throughout normal development and contributes to numerous disease etiologies, including tumorigenesis and neurological disorders. …

• Publications

  MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data

  Single-cell transcriptomics reveals gene expression heterogeneity but suffers from stochastic dropout and characteristic bimodal expression distributions in which expression is either strongly non-zero or non-detectable. …

• Publications

  Classification of low quality cells from single-cell RNA-seq data

  Single-cell RNA sequencing (scRNA-seq) has broad applications across biomedical research. …

• Publications

  CEL-Seq2: sensitive highly-multiplexed single-cell RNA-seq

  Single-cell transcriptomics requires a method that is sensitive, accurate, and reproducible. …

• Publications

  SINCERA: a pipeline for single-cell RNA-seq profiling analysis

  A major challenge in developmental biology is to understand the genetic and cellular processes/programs driving organ formation and differentiation of the diverse cell types that comprise the embryo. …

• Publications

  Sexual cell-fate reprogramming in the ovary by DMRT1

  Transcription factors related to the insect sex-determination gene doublesex (DMRT proteins) control sex determination and/or sexual differentiation in diverse metazoans and are implicated in transitions between sex-determining mechanisms during vertebrate evolution [1]. …

• Publications

  Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells

  Hematopoietic stem cells (HSCs) are a rare cell type with the ability of long-term self-renewal and multipotency to reconstitute all blood lineages. …

• Publications

  Single cell dissection of early kidney development: multilineage priming

  We used a single cell RNA-seq strategy to create an atlas of gene expression patterns in the developing kidney. …

• Publications

  A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis

  The search for effective treatments for obesity and its comorbidities is of prime importance. …

• Publications

  Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq

  The mouse olfactory mucosa is a complex chemosensory tissue composed of multiple cell types, neuronal and non-neuronal. …

• Publications

  Subtype-selective small molecule inhibitors reveal a fundamental role for Na_V1.7 in nociceptor electrogenesis, axonal conduction and presynaptic release

  Human genetic studies show that the voltage gated sodium channel 1.7 (Nav1.7) is a key molecular determinant of pain sensation. …

• Publications

  Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow

  Mouse conventional dendritic cells (cDCs) can be classified into two functionally distinct lineages: the CD8α(+) (CD103(+)) cDC1 lineage, and the CD11b(+) cDC2 lineage. …

• Publications

  Single mammalian cells compensate for differences in cellular volume and DNA copy number through independent global transcriptional mechanisms

  Individual mammalian cells exhibit large variability in cellular volume, even with the same absolute DNA content, and so must compensate for differences in DNA concentration in order to maintain constant concentration of gene expression products. …