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306 results found in Imaging Mass Cytometry

  • consumable

    Anti-Human Smooth Muscle Actin (1A4)-141Pr—25 µg

    Alpha smooth muscle actin is a 42 kDa cytoskeletal protein expressed in smooth muscle cells of blood vessels, myofibroblasts and myoepithelial cells. …

    Product #: 3141017D

  • consumable

    Anti-Human p53 (DO-7)-143Nd—25 µg

    p53 is a 53 kDa protein that operates as a tumor suppressor and helps regulate hundreds of genes in response to various types of stress. …

    Product #: 3143026D

  • consumable

    Anti-Vimentin (D21H3)-143Nd—25 µg

    Vimentins are class-III intermediate filaments found in various nonepithelial cells, especially mesenchymal cells. …

    Product #: 3143027D

  • consumable

    Anti-pTyrosine (P-Tyr-100)-144Nd—25 µg

    Tyr100 recognizes phosphorylated tyrosine residues in all proteins. An increase in total cellular phosphotyrosine levels indicates a shift in the balance of tyrosine protein kinases and phosphases. …

    Product #: 3144024D

  • consumable

    Anti-Human T-bet/TBX21 (D6N8B)-145Nd—25 µg

    T-bet (Tbx21) is a transcription factor bearing a T-box DNA-binding domain. It is considered a master-regulator of the Th1 CD4+ T cell subset. …

    Product #: 3145015D

  • consumable

    Anti-Human/Mouse BCL-6 (K112-91)-147Sm—25 µg

    BCL-6 is expressed in B and T cells. In B cells, BCL-6 induces proliferation, antibody class switching, and affinity maturation. In T cells, BCL-6 is required for programming of TFH cell generation. …

    Product #: 3147020D

  • consumable

    Anti-p4E-BP1 [T37/T46] (236B4)-149Sm—25 µg

    4E-BP1, also known as PHAS-1, is a member of the 4E-BP (eIF4E-binding protein) family of translational repressors, which also includes 4E-BP2 and 4E-BP3. …

    Product #: 3149023D

  • consumable

    Anti-Human Syk (4D10.2)-149Sm—25 µg

    Syk is a cytoplasmic 72 kDa nonreceptor tyrosine kinase that plays an important role in intracellular signal transduction in hematopoietic cells. …

    Product #: 3149024D

  • consumable

    Anti-Human CD15 (W6D3)-149Sm—25 µg

    CD15, also known as LewisX, 3-FAL and SSEA-1, is a carbohydrate adhesion molecule, 3-fucosyl-N-acetyllactosamine (3-FAL). …

    Product #: 3149026D

  • consumable

    Anti-Human/Mouse CD11b (EPR1344)-149Sm—25 µg

    CD11b, also known as Mac-1, is a transmembrane glycoprotein known to be involved in cell adhesion and phagocytosis. …

    Product #: 3149028D

  • consumable

    Anti-Human PD-L1 (E1L3N)-150Nd—25 µg

    PD-L1, also known as CD274, is one of the ligands for programmed death 1 (PD-1), and is an immune-inhibitory receptor belonging to the CD28/cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) family. …

    Product #: 3150031D

  • consumable

    Anti-Human CD45 (D9M8I)-152Sm—25 µg

    CD45, also known as leukocyte common antigen (LCA) and T200, is expressed on the plasma membrane of all hematopoietic cells except mature red blood cells and platelets. …

    Product #: 3152018D

  • consumable

    Anti-β-actin (2F1-1)-154Sm—25 µg

    β-actin is a 42 kDa cytoplasmic protein that is one of six different actin isoforms expressed ubiquitously in all eukaryotic cells. As an essential component of the cytoskeleton, β-actin is involved in cell motility, structure and integrity. …

    Product #: 3154021D

  • consumable

    Anti-Human IDO (D5J4E)-155Gd—25 µg

    Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme that catalayzes the degradation of tryptophan to kynurenines. IDO is considered to be an immunosuppressive molecule that limits T cell proliferation and activation through trytophan starvation of T cells. …

    Product #: 3155017D

  • consumable

    Anti-Human CD68 (KP1)-159Tb—25 µg

    CD68, also known as macrosialin, is predominantly an intracellular protein found in the late endosomal compartment but can also be detected in small amounts on the surface of myeloid-derived cells. …

    Product #: 3159035D

  • consumable

    Anti-Human CD20 (H1)-161Dy—25 µg

    CD20, also known as B1 and Bp35, is a transmembrane spanning protein expressed on pre-B cells, immature and mature B cells, and some follicular dendritic cells. …

    Product #: 3161029D

  • consumable

    Anti-Human Pan-Keratin (C11)-162Dy—25 µg

    Keratins (cytokeratins) are a group of intermediate filament proteins that are mainly expressed in epithelial cells. …

    Product #: 3162033D

  • consumable

    Anti-Arginase-1 (D4E3M)-164Dy—25 µg

    Arginase enzymes catalyze the fifth and final step in the urea cycle, and they are mainly expressed in the liver. Besides its role in the hepatic urea cycle, Aginase-1 has a key immunomodulatory function that plays a role in suppressing T cells. …

    Product #: 3164027D

  • consumable

    Anti-Cytokeratin 7 (RCK105)-164Dy—25 µg

    Cytokeratin 7 (CK7) is a 54 kDa type II (or basic) keratin containing three coiled-coil domains that has been shown to interact with the EGF receptor and heat shock protein 70 kD1A. …

    Product #: 3164028D

  • consumable

    Anti-Human CD223/LAG-3 (D2G40)-153Eu—25 µg

    Lymphocyte activation gene 3 (LAG-3), also known as CD223, shares homology with CD4, and LAG-3 binding to MHC class II is thought to contribute to the negative regulation of T cell activation. …

    Product #: 3153028D