22 results found in Genetic Health
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Publications
Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus
Germline GATA1 mutations that result in the production of an amino-truncated protein termed GATA1s (where s indicates short) cause congenital hypoplastic anemia. …
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Publications
Single-cell genetic analysis using automated microfluidics to resolve somatic mosaicism
Somatic mosaicism occurs throughout normal development and contributes to numerous disease etiologies, including tumorigenesis and neurological disorders. …
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User Guide
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Publications
Immune cell profiling to guide therapeutic decisions in rheumatic diseases
Biomarkers are needed to guide treatment decisions for patients with rheumatic diseases. …
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Publications
Interferon-Stimulated Gene 15 (ISG15) Conjugates Proteins in Dermatomyositis Muscle with Perifascicular Atrophy
Dermatomyositis (DM) is an autoimmune disease involving muscle and skin. …
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Publications
Pushing the frontiers of T-cell vaccines: accurate measurement of human T-cell responses
There is a need for novel approaches to tackle major vaccine challenges such as malaria, tuberculosis and HIV, among others. …
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Publications
Guardians of the Gut – Murine Intestinal Macrophages and Dendritic Cells
Intestinal mononuclear phagocytes find themselves in a unique environment, most prominently characterized by its constant exposure to commensal microbiota and food antigens. …
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system
EP1
Efficient, economical endpoint PCR results in hours with just minutes of hands-on time …
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resource
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Protocol
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resource
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technical note
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Publications
Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus
Activation of Toll-like receptors (TLRs) induces inflammatory responses involved in immunity to pathogens and autoimmune pathogenesis, such as in patients with systemic lupus erythematosus (SLE). …
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Publications
The Rectal Cancer microRNAome – microRNA Expression in Rectal Cancer and Matched Normal Mucosa
miRNAs play a prominent role in a variety of physiologic and pathologic biologic processes, including cancer. …
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Publications
Soy Improves Cardiometabolic Health and Cecal Microbiota in Female Low-Fit Rats
Phytoestrogen-rich soy is known to ameliorate menopause-associated obesity and metabolic dysfunction for reasons that are unclear. …
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Publications
Integrated time-lapse and single-cell transcription studies highlight the variable and dynamic nature of human hematopoietic cell fate commitment
Individual cells take lineage commitment decisions in a way that is not necessarily uniform. …
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faq
Why do I need to do a quality control check on my raw sequencing data?
A quality control check on raw sequencing data produces better mapping results. …
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faq
Why can’t I load the samples in the assay inlets and the assays in the sample inlets?
The sample and assay chambers inside the IFC are different sizes. …
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event
American Association for Cancer Research
AACR 2015 …
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event
Beyond Biology's Next Frontier
An evening exploring the promise of single-cell science …