Consumables

Anti-Cleaved Caspase 3 (5A1E)-172Yb—25 µg

Caspase-3 (CPP32/Yama/apopain) is a 32 kDa cysteine protease that is activated during the early stages of apoptosis. Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments, which associate to form the active enzyme. Caspase-3 is either partially or totally responsible for the proteolytic cleavage of many key proteins in the apoptotic pathway, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP). Caspase-3 expression is widely distributed. Cells of lymphoid origin express high levels, and active caspase-3 is a marker for cells undergoing apoptosis. Caspase-3 also plays an important role in morphogenetic cell death during development of the mammalian brain. The 5A1E antibody reacts with the active cleaved form of caspase-3.

• Species:
  Cross, Human
• Clone:
  5A1E
• Target:
  Caspase-3 cleaved
• Tag:
  172Yb
• Quantity:
  25µg
• Sample Type:
  FFPE