Perforin is a 66 kDa cytotoxic effector molecule primarily released by CD8+ T cells and natural killer (NK) cells to eliminate infected or dangerous cells via the perforin/granzyme cell death pathway. Perforin-mediated cytotoxicity is also involved in the homeostatic regulation of CD4+ and CD8+ T cells in vivo in a physiologic function distinct from pathogen clearance. Perforin-deficient mice are susceptible to increases in CD8+ T cell activation and in IFN-g production in response to distinct stimuli. In humans, impaired perforin-dependent cytotoxic function leads to excessive T cell activation, severe hyperinflammation, and the often fatal disorder hemophagocytic lymphohistiocytosis.
Anti-Mouse Perforin (OMAK-D)-172Yb—100 Tests