BCL-6 (B cell lymphoma 6) is an 80 kDa homodimer and member of the BTB-POZ zinc finger family of transcription repressors. BCL-6 is expressed most abundantly in germinal center B cells as well as in differentiating and activated B cells. On B cells, BCL-6 induces proliferation, antibody class switching, and affinity maturation, which inhibits their differentiation to plasma cells. On T cells, BCL-6 is required for programming of TFH cell generation. BCL-6 is also expressed in some B cell lymphomas and breast cancer cells.
Anti-Human/Mouse BCL-6 (K112-91)-163Dy—100 Tests