The A8 monoclonal antibody binds specifically to CD100, a 150 kDa type I transmembrane glycoprotein also known as semaphorin 4D (Sema4D). Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development. CD100 is widely expressed in the nervous and immune systems. CD100 is expressed on T cells, with increased expression correlating with up-regulation. CD100 is also weakly expressed on NK cells, B cells, and monocytes. CD100 is thought to plays a role in lymphocyte activation.
Anti-Human CD100 (A8)-156Gd—100 Tests