CD73, also known as ecto-5'-nucleotidase, is a 70 kDa glycophosphatidylinositol (GPI)-linked 5'-nucleotidase. CD73 is expressed on bone marrow-derived multipotent mesenchymal stem cells (MSCs) and is one of the three positive markers for identifying MSCs. CD73 is expressed on follicular dendritic cells, epithelial cells, endothelial cells and subsets of T and B lymphocytes, where its expression increases during development. CD73 catalyzes the dephosphorylation of adenosine monophosphate (AMP), converting it to adenosine. There is also evidence that CD73 can mediate costimulatory signals in T cell activation and adhesion of lymphocytes to endothelium.
Anti-Mouse CD73 (TY/11.8)-154Sm—100 Tests