CD182, also known as CXCR2 or IL-8 receptor B (IL-8RB), is a 67–70 kDa member of the 7-transmembrane-spanning G protein-coupled receptor (GPCR) family. CD182 is expressed as a homodimer, or a heterodimer with CD181 (CXCR1, IL-8RA), and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes, and oligodendrocytes. CD182 mediates neutrophil activation and chemotaxis, megakaryocytic proliferation, and angiogenesis upon binding its ligands including IL-8 (CXCL8), NAP-2 (CXCL7), GCP-2 (CXCL6), and GRO-α,β,γ (CXCL1, CXCL2, CXCL3).
Anti-Human CD182/CXCR2 (5E8/CXCR2)-147Sm—100 Tests
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Species:Human
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Clone:5E8/CXCR2
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Target:CD182
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Tag:147Sm
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Quantity:100 Tests
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