CD196, also known as CCR6 (CC chemokine receptor type 6), is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6-positive cells and the CCR6 ligand, CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. It can mediate the arrest of T cells and has been reported to be highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have also been implicated in the pathogenesis of various inflammatory autoimmune diseases, playing a role in the recruitment of Th17 cells.
Anti-Human CD196/CCR6 (11A9)-141Pr—50 Tests