Hyperion Imaging System Publications

Browse our catalog of Hyperion™ Imaging System-related publications to see how Imaging Mass Cytometry™ systems from Fluidigm empower researchers to make breakthrough discoveries.

• Overview

  Number of papers per research area as of May, 2019

  Number of cumulative papers as of May, 2019

• Recent

  • Lymphocyte mass cytometry identifies a CD3–CD4+ cell subset with a potential role in psoriasis
    Guo, R., Zhang, T., Meng, X. et al. JCI Insights (2019): doi: 10.1172/jci.insight.125306
  • Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells
    Good, Z., Borges, L., Vivanco Gonzalez, N. et al. Nature Biotechnology (2019): doi: 10.1038/s41587-019-0033-2.
  • Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells
    Good, Z., Borges, L., Vivanco Gonzalez, N. et al. Nature Biotechnology (2019): doi: 10.1038/s41587-019-0033-2.
  • Memory CD4+ T cells are generated in the human fetal intestine
    Li, N., van Unen, V., Abdelaal, T. et al. Nature Immunology (2019): doi: 10.1038/s41590-018-0294-9
  • A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry
    Damond, N., Engler, S., Zanotelli, V.R.T. et al. Cell Metabolism (2019): doi: 10.1016/j.cmet.2018.11.014

• Research Areas

  • Data Analysis Methods

    • Mass synaptometry: High-dimensional multi parametric assay for single synapses
      Gajera, C.R., Fernandez, R., Postupna, N. et al. Journal of Neuroscience Methods (2019): 73–83
    • Compensation of signal spillover in suspension and Imaging Mass Cytometry
      Chevrier, S., Crowell, H.L., Zanotelli, V.R.T. et al. Cell Systems (2018): 612–20
    • histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data
      Schapiro, D., Jackson, H.W., Raghuraman, S. et al. Nature Methods (2017): 873–6
    • Automatic single cell segmentation on highly multiplexed tissue images
      Schüffler, P.J., Schapiro, D., Giesen, C. et al. Cytometry, Part A; (2015): 936–42

  • IO

    • Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry
      Carvajal-Hausdorf, D.E., Patsenker, J., Stanton, K.P. et al. Clinical Cancer Research (2019): doi: 10.1158/1078-0432.CCR-18-2599
    • Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma
      Raj, D., Yang, M.H., Rodgers, D. et al. Gut (2018): doi: 10.1136/gutjnl-2018-316595
    • Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma
      Chew, V., Lee, Y.H., Nasir, N.J.M. et al. Gut (2018): doi: 10.1136/gutjnl-2017-315485

  • Immunology

    • Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States
      Wei, S.C., Sharma, R., Anang, N.A.S. et al. Immunity (2019): doi: 10.1016/j.immuni.2019.03.004
    • Memory CD4+ T cells are generated in the human fetal intestine
      Li, N., van Unen, V., Abdelaal, T. et al. Nature Immunology (2019): doi: 10.1038/s41590-018-0294-9
    • Opposing Roles of Dendritic Cell Subsets in Experimental GN
      Brähler, S., Zinselmeyer, B.H., Raju, S. et al. Journal of the American Society of Nephrology (2018): 138–54

  • Immunophenotyping

    • Lymphocyte mass cytometry identifies a CD3–CD4+ cell subset with a potential role in psoriasis
      Guo, R., Zhang, T., Meng, X. et al. JCI Insights (2019): doi: 10.1172/jci.insight.125306
    • High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease
      Mrdjen, D., Pavlovic, A., Hartmann, F.J. et al. Immunity (2018): 380–95

  • Inherited Disease

    • Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes
      Wang, Y.J., Traum, D., Schug, J. et al. Cell Metabolism (2019): doi: 10.1016/j.cmet.2019.01.003
    • A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry
      Damond, N., Engler, S., Zanotelli, V.R.T. et al. Cell Metabolism (2019): doi: 10.1016/j.cmet.2018.11.014

  • Liquid Biopsy

    • Multiplex protein detection on circulating tumor cells from liquid biopsies using imaging mass cytometry
      Gerdtsson, E., Pore, M., Thiele, J.A. et al. Convergent Science Physical Oncology (2018): 015002

  • Method Development

    • TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry
      Bassan, J., Willis, L.M. Vellanki, R.N. et al. Proceedings of the National Academy of Sciences (2019): doi: 10.1073/pnas.1821151116
    • Mass Spectrometry Imaging and Integration with Other Imaging Modalities for Greater Molecular Understanding of Biological Tissues
      Porta Siegel, T., Hamm, G., Bunch, J. et al. Molecular Imaging and Technology (2018): 888-901
    • Ruthenium Counterstaining for Imaging Mass Cytometry
      Catena, R., Montuenga, L.M., Bodenmiller, B. Journal of Pathology (2018): 479–84
    • Simultaneous Detection of Protein and mRNA in Jurkat and KG-1a Cells by Mass Cytometry
      Mavropoulos, A., Allo, B., He, M. et al. Cytometry Part A (2017): 1,200–8
    • Analytical figures of merit for a novel tissue imaging system
      Straus, R.N., Carew, A., Sandkujil, D. et al. Journal of Analytical Atomic Spectrometry (2017): 1,044–51
    • Staining of frozen and formalin-fixed, paraffin-embedded tissues with metal-labeled antibodies for Imaging Mass Cytometry analysis
      Chang, Q., Ornatsky, O., Hedley, D. Current Protocols in Cytometry (2017): 12.47.1–12.47.8
    • Imaging Mass Cytometry
      Chang, Q., Ornatsky, O.I., Siddiqui, I. et al. Cytometry Part A (2017): 160–9
    • Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry
      Giesen, C., Wang, H.A., Schapiro, D. et al. Nature Methods (2014): 417–22

  • Oncology

    • Simultaneous Multiplexed Imaging of mRNA and Proteins with Subcellular Resolution in Breast Cancer Tissue Samples by Mass Cytometry
      Schulz, D., Zanotelli, V.R.T., Fischer, J.R. et al. Cell Systems (2018): 25–36
    • Clonal diversity revealed by morphoproteomic and copy number profiles of single prostate cancer cells at diagnosis
      Malihi, P.D., Morikado, M., Welter, L. et al. Convergent Science Physical Oncology (2018): doi: 10.1088/2057-1739/aaa00b
    • Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues
      Chang, Q., Ornatsky, O.I., Siddiqui, I. et al. Scientific Reports (2016): 36,641

  • Review

    • New tools for pathology: a user’s review of a highly multiplexed method for in situ analysis of protein and RNA expression in tissue
      Decalf, J., Albert, M.L., Ziai, J. Journal of Pathology (2019): 650-61